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Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.

Characterization of the effects of complement- and inflammasome-mediated inflammation on choroidal neovascularization in a mouse model of neovascular age-related macular degeneration suggests synergistic benefits from targeting both forms of inflammation.

Electrically active axons in white matter stimulate their own myelination by releasing glutamate, which signals through AMPA-type glutamate receptors on nearby oligodendrocyte precursors and newly-differentiating oligodendrocytes, enhancing their survival and hence their ability to myelinate.

Spontaneous remyelination is a common phenomenon in the marmoset experimental autoimmune encephalomyelitis model, reliably detected using in vivo magnetic resonance imaging, rendering this an indispensable model to further investigate the pathobiology of remyelination in multiple sclerosis.

Single cell RNA, protein and electrophysiology data revealed that combinatorial availability of three auxiliary subunit isoforms of a single ion channel is sufficient for generating distinct, input frequency-sensitive firing phenotypes.

Immunolabelling and morphological assessment, complemented by complete transcriptomic analysis, demonstrates that supporting cells can be induced to convert towards a hair cell-like phenotype in human vestibular sensory epithelia.

A new technique called ‘siGOLD’ allows neural circuits to be mapped using a combination of antibody labeling and electron microscopy.

Proteomic analysis in a novel cell-free system for the study of mitophagy, identifies candidate proteins involved in the enforcement of clonal, maternal inheritance of mitochondria and mitochondrial genes in mammals.

Plant roots can rapidly change the acidity of their cell walls and the root-soil interface to efficiently navigate in the soil environment.

Mice lacking the membrane-shaping protein syndapin III show severe reduction of caveolae reminiscent of human caveolinopathies but maintain plasma membrane-associated caveolar coats proteins and thereby unveil physiological impairments associated with lack of invaginated caveolae.