4 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    An open-source computational and data resource to analyze digital maps of immunopeptidomes

    Etienne Caron et al.
    A community-based international effort generates standardized HLA allele-specific peptide assay libraries and enables the analysis of the human immunopeptidome by SWATH mass spectrometry.
    1. Immunology and Inflammation

    TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

    F Tudor Ilca et al.
    Immunopeptidomics in combination with novel cell-based assays that assess peptide exchange reveal a critical role for the K22-D35 loop of TAPBPR in mediating peptide dissociation and peptide selection on MHC I.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai et al.
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Computational and Systems Biology
    2. Developmental Biology

    A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

    Bjoern Gaertner et al.
    Ribosome profiling and loss-of-function during human ESC pancreatic differentiation reveal abundant lncRNA translation and an essential role for translated LINC00261 in beta cell differentiation, likely through a trans-regulatory, microprotein-independent mechanism.

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