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pYtags are novel biosensors that can be used to measure the activity of a receptor tyrosine kinase of interest in live cells with high spatiotemporal resolution and are applied to reveal rapid activity dynamics of EGFR/ErbB2 signaling.

The combination of molecular imaging, genetic and pharmacological approaches revealed that BCR signaling and PKCβ-dependent activation of focal adhesion kinase (FAK) is required for B cell mechanosensing.

A toxin produced by the bacterium Bordetella pertussis preferentially binds to non-activated integrin complement receptor 3 outside of its ligand-binding I-domain and efficiently blocks downstream signaling of the integrin through elevation of cytosolic cAMP.

Evolution-guided structure-function analyses reveal that CD4 transmembrane and intracellular juxtamembrane motifs play a more profound role in initiating pMHCII-specific TCR-CD3 signaling than previously characterized CD4-Lck interactions.

The MADA motif is functionally conserved across NLRs from distantly related plants and has degenerated in sensor NLRs over evolutionary time.

Direct control of ligand binding half-life with light shows that lifetime strongly affects T cell signaling.

Angiopoietin-like proteins signal through notch via receptor interaction and can regulate Notch cleavage/activation.

A designer peptide inhibits the T cell receptor through allosteric binding to the transmembrane region.

In-depth proteomic analyses of intestinal tissue-resident intraepithelial T lymphocytes reveals how these cells are adapted to the intestinal environment through increased cholesterol and lipid metabolism, tailored metabolic profiles, receptors for interacting with epithelial cells, and tightly regulated signalling pathways.

The B cell receptors of naïve B cells need higher levels of mechanical force to be fully activated than those of memory B cells.