Tregs form an "immunosuppressive ring" around solid tumors that is broken down during adoptive cell therapy and cyclophosphamide combination immunotherapy.

Peptide immunotherapy in mice depends upon sustained expression of co-inhibitory protein PD-1 in T cells.

Engineered T cell receptors enable targeted immunotherapy with a reduced risk of harmful autoimmunity.

Building on previous work (Lasagna-Reeves et al., 2015) it is shown that polyglutamine ATXN1 oligomers propagate locally in SCA1 mice, and that passive immunotherapy targeting soluble oligomers can lead to an improvement in motor coordination and a modest increase in life span.

Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?

Driving melanoma differentiation through G protein-coupled estrogen receptor signaling decreases proliferative capacity, decreases expression of the oncodriver and stem cell marker c-Myc, and increases the effectiveness of immunotherapy.

Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.

The survival of patients with cutaneous melanoma can be accurately predicted using just four DNA methylation marks.

The National Institutes of Health needs to make radical changes to ensure that biomedical research continues to thrive in the United States.

The occurrence, progression and treatment of cancer may be linked to changes in the nature of stemness.