84 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

    Kira M Düsterwald et al.
    Mathematical models with experimental validation show that chloride transporters in the cell membrane, and not negatively charged impermeant molecules, generate the driving force used by GABA receptors to silence neurons.
    1. Cell Biology
    2. Neuroscience

    The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

    Heather S Comstra et al.
    The ATP7A interactome is the first comprehensive view of putative Menkes disease neurodegeneration mechanisms.
    1. Cell Biology

    A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

    Lori Clay et al.
    Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A family of fluoride-specific ion channels with dual-topology architecture

    Randy B Stockbridge et al.
    Efflux of xenobiotic fluoride from microorganisms occurs through a novel family of ion channels with stringent selectivity for fluoride ion and dual-topology molecular architecture.
    1. Neuroscience

    A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

    Nan Jiang et al.
    Epidermal cells in vertebrates and invertebrates ensheath portions of somatosensory neurons via a conserved morphogenetic mechanism, and this ensheathment regulates morphogenesis and function of Drosophila nociceptive neurons.
    1. Neuroscience
    2. Physics of Living Systems

    Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea

    Mélanie Tobin et al.
    The tip-link complex of the hair cell is mechanically tuned along the tonotopic axis of the cochlea.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    An intracellular anion channel critical for pigmentation

    Nicholas W Bellono et al.
    Oculocutaneous albinism II (OCA2) contributes to a melanosome-specific anion channel that modulates organellar pH and is critical for melanin synthesis.
    1. Cell Biology

    TRPV4 is the temperature-sensitive ion channel of human sperm

    Nadine Mundt et al.
    The molecular identity of the temperature-sensitive ion channel of human sperm that ensures depolarization is TRPV4.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal opening of the store-operated calcium channel Orai

    Xiaowei Hou et al.
    The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.
    1. Structural Biology and Molecular Biophysics

    Structure of the human volume regulated anion channel

    Jennifer M Kefauver et al.
    The homomeric structure of human SWELL1 (LRRC8A) provides insights into properties of a novel chloride channel family.

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