Browse the search results

Page 2 of 28
    1. Chromosomes and Gene Expression

    Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

    Clair Harris et al.
    The PRC2 Polycomb complex made in the mouse oocyte prevents transcriptional inactivation of the maternal X-chromosome in the early embryo.
    1. Developmental Biology

    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

    Jadiel A Wasson et al.
    Epigenetic reprogramming by LSD1/KDM1A acts at fertilization in mice to enable embryogenesis and prevent behavioural abnormalities.
    1. Plant Biology

    Non-canonical RNA-directed DNA methylation participates in maternal and environmental control of seed dormancy

    Mayumi Iwasaki et al.
    Seed-specific and cold-induced DNA methylation is deposited in the seed progeny to form a transient and transgenerational memory of past environmental conditions to optimize seed germination timing.
    1. Epidemiology and Global Health

    Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults

    Flavia Camponovo et al.
    Malaria pre-exposed volunteers exhibit large breadth of humoral immune responses, with strong variation between individuals, which might compromise vaccine-induced humoral immune response due to natural imprinting.
    1. Developmental Biology
    2. Genetics and Genomics

    Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

    Daniel Andergassen et al.
    Allele-specific expression due to genetic differences, X-chromosome inactivation or genomic imprinting, varies dynamically throughout development, and may be explained by allele-specific differences in stability or the actions of tissue-specific enhancers.
    1. Neuroscience

    Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior

    Anton Fomenko et al.
    Transcranial low-intensity ultrasound applied in block design and at low duty cycles and longer sonication durations can safely and non-invasively suppress human motor-evoked potentials, possibly via GABA-A-mediated inhibitory pathways.
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl et al.
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Neuroscience

    Assembly rules for GABAA receptor complexes in the brain

    James S Martenson et al.
    A novel GABAAR assembly pathway that promotes synaptic inhibition is established and provides a molecular explanation for how GABAARs with distinct subunit compositions display distinct subcellular distributions.