There are many fine-scale scene-selective areas within the visual system, beyond the occipital, temporal, and medial place areas, whose function may be key to performing complex tasks in dynamic environments.
The proteasomal deubiquitinase UCHL5/UCH37 uses a face distinct from the canonical ubiquitin binding site to engage K48-linked ubiquitin chains and catalyze chain debranching.
Extremely significant interactions between α3-β7 and β12-α5 loops in the tetrameric L1 metallo-β-lactamase play an important role in the structural remodeling of the active site and offer insights into the potential for novel drug development by exploiting these interactions.
In situ structural analysis of bacterial flagellar motor in the Lyme disease spirochete reveals novel conformational change driven by proton motive force.
Cryo-electron microscopy has been used to provide a structural interpretation of the complete action cycle of release factor 3 during translation termination, which includes a coordinated sequence of interactions with a class-I release factor and the ribosome.
Steven De Gieter, Casey I Gallagher ... Rouslan G Efremov
Cryo-EM structures of Cys-loop receptor Alpo4 from the thermophilic worm Alvinella pompejana show that a sterol derivative CHAPS binds in and outside of its orthosteric binding site and induces a quaternary twist.
Angela M Phillips, Daniel P Maurer ... Michael M Desai
An anti-influenza receptor binding site antibody acquires breadth through hierarchical sets of epistatic mutations distributed across the light and heavy chains, demonstrating how mutations can interact to shape the evolution of antibody breadth in various antigen exposure regimens.
