2,067 results found
    1. Cell Biology

    Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

    Toru Hiratsuka et al.
    In vivo imaging of extracellular signal-regulated kinase activity reveals radial ERK activation patterns that are associated with cell cycle progression in the mouse epidermis.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging

    Nicholas James Sofroniew et al.
    An optical microscopy approach with an ultra-large field of view but retained subcellular resolution allows simultaneous imaging of neural activity in widely dispersed brain regions.
    1. Neuroscience

    Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators

    Kristen M Smith-Edwards et al.
    Inflammatory pain, previously thought to result from increased activity in "pain" neurons, may in fact be due to wholesale changes in afferent output that includes increased and decreased activity that the brain interprets as pain.
    1. Developmental Biology and Stem Cells

    Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina

    Katharina Lust, Joachim Wittbrodt
    Müller glia cells in the medaka (Oryzias latipes) retina act as lineage restricted progenitors which only regenerate photoreceptors but can be activated to perform as potent stem cells using Sox2.
    1. Neuroscience

    Mouse V1 population correlates of visual detection rely on heterogeneity within neuronal response patterns

    Jorrit S Montijn et al.
    Heterogeneity of neural responses in mouse cortex correlates better with visual detection than mean population activity.
    1. Cell Biology

    In vivo super-resolution RESOLFT microscopy of Drosophila melanogaster

    Sebastian Schnorrenberg et al.
    Building on previous work (Grotjohann et al., 2012), low-light super-resolution microscopy has been performed on living transgenic Drosophila larvae and tissues.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Physical limits of flow sensing in the left-right organizer

    Rita R Ferreira et al.
    Large-scale in vivo imaging of the zebrafish left-right organizer (Kupffer's vesicle) combined with fluid dynamics calculations allows to quantitatively test the possible flow detection mechanisms and supports the flow transport of chemical signals as the mechanism of side determination.
    1. Neuroscience

    Diverse modes of synaptic signaling, regulation, and plasticity distinguish two classes of C. elegans glutamatergic neurons

    Donovan Ventimiglia, Cornelia I Bargmann
    Single-neuron synaptic imaging in vivo demonstrates that highly conserved molecules such as UNC-13, UNC-18, and protein kinase C, which are found at essentially every synapse make different functional contributions in Caenorhabditis elegans glutamatergic neurons.
    1. Neuroscience

    Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions

    Weijian Yang et al.
    An all-optical 3D two-photon imaging and photostimulation platform was demonstrated, with the capability to precisely stimulate a large group of cells in mice cortex in vivo with low laser power.
    1. Neuroscience

    Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images

    Rohan Gala et al.
    BoutonAnalyzer software makes it possible to detect axonal boutons and measure their structural plasticity in long-term in vivo imaging experiments.

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