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    1. Cell Biology
    2. Neuroscience

    Functional interdependence of the actin nucleator Cobl and Cobl-like in dendritic arbor development

    Maryam Izadi et al.
    Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.
    1. Microbiology and Infectious Disease

    A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites

    Zachary K Barth et al.
    Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction.
    1. Medicine
    2. Neuroscience

    Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

    Shai Kellner et al.
    Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Method development and characterisation of the low-molecular-weight peptidome of human wound fluids

    Mariena JA van der Plas et al.
    Peptidomics method development and analysis of qualitative differences of peptide patterns in human wound fluids provide potential biomarkers for wound healing and infection.
    1. Cell Biology

    ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells

    Maria F Ullo, Jeremy S Logue
    Fast amoeboid migrating cells require both cofilin-1 and ADF for fast actin turnover at 'leader bleb' necks.
    1. Biochemistry and Chemical Biology

    The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains

    Alan Rodriguez Carvajal et al.
    The E3 ubiquitin ligase complex linear ubiquitin chain assembly complex (LUBAC) forms a branched chain on linear ubiquitin chains depending on the RING-in-between-RING-type E3 ligase heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L).
    1. Cell Biology
    2. Developmental Biology

    Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

    Helen Schmidt et al.
    P granule assembly depends in part on protein-protein interactions that drive condensation independent of RNA.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

    Vicente Perez-Garcia et al.
    BAP1/ASXL is a key regulator of trophoblast invasion during early mouse and human placentation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

    Tisha E Bohr et al.
    Loss of a single organ, the planarian pharynx, triggers immediate proliferation and expansion of stem cells required to replace it.
    1. Cell Biology

    Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

    Lara Katharina Krüger et al.
    During anaphase B spindle elongation, Klp9 controls the speed of both microtubule sliding and microtubule growth to coordinate the processes and thus maintain spindle stability for faithful chromosome separation.