A robot capable of automatically obtaining blind whole cell patch clamp recordings from multiple neurons simultaneously guides four interacting electrodes in a coordinated fashion, avoiding mechanical coupling in the brain.

A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.

A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.

Optical recordings reveal previously unknown neuromodulator dynamics in the striatum during animal movements that suggest a new interpretation of the underpinnings of bradykinetic movements exhibited in Parkinson's Disease patients.

The most vulnerable motor units lose a fundamental firing property before the denervation of their muscle fibers in ALS mice, changing our view of the role of excitability in neurodegeneration.

When the fear-enhancing effects of prior exposure to stress are absent, the expression of fear reflects normal neural activity in the medial prefrontal cortex, not stress-induced hyperactivity in the amygdala.

Optogenetics and in vivo recordings in mice reveal that pauses in cholinergic interneurons offer an alternative mechanism to inhibit subthreshold and suprathreshold events of spiny projection neurons.

In vivo recordings in unanesthetized zebrafish larvae show that Purkinje neurons have two stable membrane potential states and that climbing fiber inputs can toggle them to up states during motor episodes.

Multi-fiber photometry recording and circuit-based manipulation in vivo identify a long-range SuM-DG circuit linking two highly correlated subcortical regions to regulate spatial memory retrieval through SuM glutamate transmission.

In vivo recordings and computational modeling of the electrosensory lobe of mormyrid fish provide a circuit-level description of how learning generalizes to new situations.