970 results found
    1. Computational and Systems Biology

    Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics

    Mayank Baranwal, Ryan L Clark ... Ophelia S Venturelli
    Recurrent neural network models enable prediction and design of health-relevant metabolite dynamics in synthetic human gut communities.
    1. Physics of Living Systems

    Geometric control of myosin II orientation during axis elongation

    Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
    During Drosophila axis elongation, the orientational pattern of the cytoskeleton is in good approximation stationary, while the genes thought to instruct these patterns are transported with the tissue flow.
    1. Cancer Biology

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Zeyad D Nassar, Chui Yan Mah ... Lisa M Butler
    DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
    1. Microbiology and Infectious Disease

    Host and viral determinants of airborne transmission of SARS-CoV-2 in the Syrian hamster

    Julia R Port, Dylan H Morris ... Vincent J Munster
    An experimental animal model provides further insights into the host and viral mechanisms underlying airborne transmission of SARS-CoV-2.
    1. Developmental Biology

    Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in Drosophila

    Satish Kumar Tiwari, Ashish Ganeshlalji Toshniwal ... Lolitika Mandal
    Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in Drosophila..
    1. Developmental Biology
    2. Plant Biology

    A stochastic multicellular model identifies biological watermarks from disorders in self-organized patterns of phyllotaxis

    Yassin Refahi, Géraldine Brunoud ... Christophe Godin
    A stochastic model of phyllotaxis can explain the striking irregularities observed in the spiral patterns of plants and predicts that perturbation patterns provide key information about the underlying biochemical mechanisms.
    1. Cell Biology

    ARHGAP18-ezrin functions as an autoregulatory module for RhoA in the assembly of distinct actin-based structures

    Andrew T Lombardo, Cameron AR Mitchell ... Anthony Bretscher
    ARHGAP18 specializes in controlling cell shape at the topmost layer of the cell membrane by regulating the interaction between the ERM protein family, RhoA signaling, and the actin cytoskeleton.
    1. Microbiology and Infectious Disease

    A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

    Aurélia C Balestra, Mohammad Zeeshan ... Mathieu Brochet
    Multiple steps of the atypical cell cycles underlying Plasmodium gametogony are controlled by a divergent cyclin/cyclin-dependent complex.
    1. Neuroscience

    Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques

    Nico A Flierman, Sue Ann Koay ... Chris I De Zeeuw
    Dentate nucleus neurons can dynamically modulate their activity during a visual attention task, comprising not only sensorimotor but also cognitive attentional components.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells

    Christopher D Todd, Özgen Deniz ... Miguel R Branco
    Genetic and epigenetic editing experiments establish causal links between transposon-derived enhancers and gene regulation in mouse embryonic and extraembryonic lineages.

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