Adult male, but not female, rats showed altered neuronal function, inhibited synaptic plasticity and diminished social behavior following cannabinoid exposure during gestation in a model of cannabis use during pregnancy.
Prenatal ethanol exposure results in aberrant tangential migration by altering NKCC1-mediated chloride homeostasis that can be mitigated by bumetanide.
FGF signaling is crucial for gyrus formation, proliferation of outer radial glial cells and expansion of upper layers of the cerebral cortex in gyrencephalic mammals.
Loss miRNA maturation in proopiomelanocortin (POMC) neurons causes metabolic dysregulation and favors the differentiation of Pomc progenitors into neuropeptide Y neurons, a developmental process that appears to specifically involve miR-103/107.
A high axonal chloride concentration explains why activation of light-gated chloride channels causes neurotransmitter release, and a novel hybrid somatodendritic targeting motif ameliorates this phenomenon and improves their inhibitory function.
The APP intracellular domain (AICD) physiologically regulates synaptic GluN2B-containing NMDA receptor current, a process that could contribute to pathological Alzheimer's disease-related synaptic failure upon increase of AICD levels in adult neurons.
PLK-1/2-mediated SYP-4 phosphorylation is dependent on crossover precursor formation, triggering a switch in the dynamic state of the synaptonemal complex that reduces the formation of further double-strand breaks at late meiotic prophase.
Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
