152 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Immune genes are hotspots of shared positive selection across birds and mammals

    Allison J Shultz, Timothy B Sackton
    Pathogens, particularly viruses, target the same genes over deep evolutionary time, resulting in shared signatures of positive selection and transcriptional responses at the same genes.
    1. Microbiology and Infectious Disease

    A multicellular way of life for a multipartite virus

    Anne Sicard et al.
    A multipartite virus functionally spreads its distinct genome segments in distinct individual cells of the host plant, and complementation of the viral genes across cells allows a pluricellular infection cycle.
    1. Neuroscience

    Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

    Elizabeth A Gould et al.
    Mild myelin disruption leads to early axonal pathology, a novel pathological response in neural stem cells, regionally increased oligodendrocytes and altered behavior.
    1. Cell Biology

    Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation

    Amy M Winans et al.
    Waves of polymerizing actin work in concert with microtubule polymerization to lay down more microtubules tracks and transiently increase microtubule-based transport into the growing neurite.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

    Maja Šolman et al.
    Rare mutations in the switch III region of Ras can increase its nanoscale clustering, which enhances effector recruitment and downstream signaling.
    1. Cancer Biology
    2. Cell Biology

    Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

    Xiaolei Li et al.
    Leukemia-Related Protein 16 (LRP16), a member of the macro domain family, plays a crucial role in orchestrating genotoxicity-initiated NF-κB signaling in the colon and the pathophysiological relevance of NF-κB activation induced by LRP16 in colonic cell survival/recovery from extrinsic DNA damage.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration

    Zachary F Hallberg et al.
    A newfound signaling enzyme that diverged from a protein family ubiquitous in bacteria provides mechanistic insights into how new signaling activity emerges to control distinct cellular function and physiology.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long et al.
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.

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