4,384 results found
    1. Neuroscience

    Odor-evoked category reactivation in human ventromedial prefrontal cortex during sleep promotes memory consolidation

    Laura K Shanahan et al.
    Odor cues in sleep evoke content-specific signatures of neural reactivation in visual and prefrontal brain areas that predict subsequent memory performance in the wake state.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

    Valeria Kalienkova et al.
    cryo-EM reveals the properties of distinct conformations occupied during activation of the lipid scramblase nhTMEM16 and provides new insights into its interactions with the lipid environment.
    1. Neuroscience

    Distinct effects of prefrontal and parietal cortex inactivations on an accumulation of evidence task in the rat

    Jeffrey C Erlich et al.
    Quantitative modeling of inactivations shows the prefrontal cortex (but not parietal cortex) of the rat is obligatory for decisions guided by evidence accumulating longer than 240 ms.
    1. Chromosomes and Gene Expression

    Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

    Clair Harris et al.
    The PRC2 Polycomb complex made in the mouse oocyte prevents transcriptional inactivation of the maternal X-chromosome in the early embryo.
    1. Immunology and Inflammation

    Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

    Zhixun Shen et al.
    Conformational changes occur within extracellular domain of BCR upon antigen engagement, and these conformational changes are related with the strength of BCR activation and are distinct in IgM- and IgG-BCR.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

    Shaogeng Tang et al.
    Building on previous work (Tang et al., 2015), novel ESCRT-III subunit Snf7 auto-activation mutants are used to reveal two parallel ubiquitin-dependent pathways during multivesicular endosome biogenesis.
    1. Cell Biology
    2. Immunology and Inflammation

    Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

    Anthony J Covarrubias et al.
    Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.
    1. Physics of Living Systems

    Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle

    Xuemeng Zhang et al.
    The Frank–Starling law of the heart and its underlying mechanism of length-dependent activation involve distinctive structural changes in both the thin and thick filaments of cardiac muscle cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

    Ji-Eun Lee et al.
    MLL4 (KMT2D) is a major mammalian H3K4 mono- and di-methyltransferase that is essential for enhancer activation, cell-type-specific gene expression, and cell differentiation.
    1. Structural Biology and Molecular Biophysics

    A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels

    Wang Zheng et al.
    A functionally conserved inactivation gate in the inner helix of Piezo channels controls the majority of the inactivation process via a hydrophobic mechanism.

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