14,933 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Na+/K+ pump interacts with the h-current to control bursting activity in central pattern generator neurons of leeches

    Daniel Kueh, William H Barnett ... Ronald L Calabrese
    The dynamic current generated Na+/K+ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.
    1. Developmental Biology

    The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system

    Sanjay Kumar Sukumar, Vimala Antonydhason ... Ruth H Palmer
    The newly characterized activity regulating neuropeptide encoding gene Spar is a transcriptional target of the Jeb/Alk receptor tyrosine kinase signaling pathway in the Drosophila nervous system.
    1. Neuroscience

    Synaptic up-scaling preserves motor circuit output after chronic, natural inactivity

    Joseph M Santin, Mauricio Vallejo, Lynn K Hartzler
    Synaptic scaling maintains motor output from the respiratory network of bullfrogs after months of inactivity in the winter, providing evidence for homeostatic plasticity in response to large ecologically relevant perturbations in neuronal activity.
    1. Neuroscience

    Genome-wide identification of neuronal activity-regulated genes in Drosophila

    Xiao Chen, Reazur Rahman ... Michael Rosbash
    Activity-regulated genes in Drosophila neurons differ from the well-characterized situation in mammals, and these genes provided a strategy to construct reporters for monitoring neuronal activity in fly brains.
    1. Neuroscience

    Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input

    Zohre Azimi, Ruxandra Barzan ... Dirk Jancke
    Serotonergic input to visual cortex controls ongoing and evoked activity in a separable manner via distinct receptor pathways.
    1. Neuroscience

    Spontaneous and evoked activity patterns diverge over development

    Lilach Avitan, Zac Pujic ... Geoffrey J Goodhill
    Spontaneous and evoked patterns of neural activity in the larval zebrafish tectum become less similar over development, in contrast with a previous hypothesis for the computational role of spontaneous activity.
    1. Neuroscience

    Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network

    Eric Hart, Alexander C Huk
    Simultaneous recordings of neural ensembles in both the frontal and parietal cortices reveal how persistent activity can be maintained in the primate brain during visuospatial working memory.
    1. Developmental Biology
    2. Immunology and Inflammation

    T cell self-reactivity during thymic development dictates the timing of positive selection

    Lydia K Lutes, Zoë Steier ... Ellen A Robey
    Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.
    1. Neuroscience

    Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

    Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell
    RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
    1. Neuroscience

    A robust activity marking system for exploring active neuronal ensembles

    Andreas T Sørensen, Yonatan A Cooper ... Yingxi Lin
    A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.

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