197 results found
    1. Cell Biology

    Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery

    Daniel G Booth, Masatoshi Takagi ... Paola Vagnarelli
    The mitotic chromosome periphery is organised by the PP1 binding protein Ki-67 and contributes to nucleolar re-activation upon mitotic exit.
    1. Neuroscience

    A neural mechanism of speed-accuracy tradeoff in macaque area LIP

    Timothy Hanks, Roozbeh Kiani, Michael N Shadlen
    To establish a trade-off between the speed and accuracy of a decision, neurons in lateral intraparietal cortex combine evidence bearing on the decision with a signal that incorporates the cost of time into the decision-making process.
    1. Neuroscience

    Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

    Christian M Gallardo, Martin Darvas ... Andrew D Steele
    For mice, knowing when it is time to feed is dependent on the neurotransmitter dopamine and the D1R receptor of neurons in the dorsal striatum.
    1. Neuroscience

    Neural mechanisms of economic commitment in the human medial prefrontal cortex

    Konstantinos Tsetsos, Valentin Wyart ... Christopher Summerfield
    A striking dissociation exists in the medial prefrontal cortex, with different brain regions responding to value when commitments are deferred to the future and when prospects are judged to be undesirable.
    1. Neuroscience

    Homeostatic reinforcement learning for integrating reward collection and physiological stability

    Mehdi Keramati, Boris Gutkin
    A mathematical model built around the assumption that the desire to maintain internal homeostasis drives the behavior of animals, by affecting their learning processes, can explain many real-world behaviors, including some that might otherwise appear irrational.
    1. Cancer Biology

    Science Forum: An open investigation of the reproducibility of cancer biology research

    Timothy M Errington, Elizabeth Iorns ... Brian A Nosek
    The Reproducibility Project: Cancer Biology will generate a high-quality dataset to explore questions about the reproducibility of research, and will make all data, analysis and other research materials openly available to the research community.
    1. Cell Biology

    COMP-1 promotes competitive advantage of nematode sperm

    Jody M Hansen, Daniela R Chavez, Gillian M Stanfield
    Nematode sperm respond to competitive environments by modulating cellular pathways involved in migration and storage to ensure their access to oocytes.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf, Olin K Silander, Erik van Nimwegen
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.

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