5,955 results found
    1. Developmental Biology

    Compartmentalized oskar degradation in the germ plasm safeguards germline development

    Catherine E Eichler et al.
    RNP granules confer temporal and spatial regulation of oskar mRNA degradation to minimize inheritance of oskar mRNAby germ cells and thereby protect germline development.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

    Lucas D Sanor et al.
    A novel CRISPR-based genetic screen of candidate regeneration genes in haploid axolotl limbs reveals two genes required for proper regeneration.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji

    Alasdair D Henderson et al.
    A combination of eight serological surveys shows a decline in seroprevalence over a two-year period following the first reports of Zika transmission in Fiji and French Polynesia.
    1. Neuroscience

    Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb

    Justin Losacco et al.
    Tetrode recordings show that the amplitude of gamma oscillations encodes for information on contextual odorant identity when observed at the peak phase of the theta oscillation in the olfactory bulb.
    1. Cancer Biology

    STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

    Jong Wook Kim et al.
    ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
    1. Neuroscience

    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

    Liang Zhou et al.
    Gab1 is a key downstream effector of PDGF signaling and essential to oligodendrocyte differentiation by linking PDGF signaling with GSK3β/β-catenin module.
    1. Neuroscience

    Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex

    Viktor Szegedi et al.
    Abundant self-inhibitory synapses in the layer 2/3 of human neocortex strongly regulate the function of basket cells.
    1. Neuroscience

    Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition

    E Mae Guthman et al.
    Sst+ interneurons drive feedforward inhibition in the basolateral amygdala, and thus provide a framework for why interneuron subtypes may mediate different archetypal circuit motifs across different brain regions.
    1. Cell Biology
    2. Neuroscience

    Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy

    Ori J Lieberman et al.
    In addition to its classic role in synaptic function and plasticity, macroautophagy regulates neuronal intrinsic excitability via degradation of acetylated Kir2 channels to control neurotransmission.
    1. Neuroscience

    Resolving multisensory and attentional influences across cortical depth in sensory cortices

    Remi Gau et al.
    The different laminar profiles observed across the cortical depth for multisensory and attentional influences indicate partly distinct neural circuitries of information-flow control.

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