3,151 results found
    1. Cell Biology
    2. Human Biology and Medicine

    Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2

    Adela Constantinescu-Bercu et al.
    The interaction between activated αIIbβ3 on platelets and SLC44A2 on circulating neutrophils facilitates neutrophil capture and drives flow-dependent NETosis.
    1. Developmental Biology

    The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle

    Husniye Kantarci et al.
    Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.
    1. Structural Biology and Molecular Biophysics

    Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses

    Ling Wang et al.
    The conformational dynamics of multidrug resistance protein 1 (MRP1) are tracked in real time by single-molecule fluorescence resonance energy transfer experiments, which elucidate the rate-limiting mechanism of MRP1's transport cycle.
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind et al.
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Cell Biology

    Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

    Yajuan Guo et al.
    Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.
    1. Developmental Biology
    2. Evolutionary Biology

    Bacterial contribution to genesis of the novel germ line determinant oskar

    Leo Blondel et al.
    Evidence suggests that the oskar gene, a critical germ line determinant in insects, was formed by fusion of bacterial and eukaryotic sequences at least 450 million years ago.
    1. Stem Cells and Regenerative Medicine

    Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

    Mi-Sun Lee et al.
    Tgfb3 inhibits Muller glial cell reprogramming and drives Muller cell quiescence in the injured zebrafish retina, thereby inhibiting retina regeneration.
    1. Developmental Biology

    Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

    Zhian Ye et al.
    Atoh1+ HC precursors survive post severe injury and activate the Yap-Lin28 pathway to restore progenitor for initiating regeneration.
    1. Developmental Biology
    2. Immunology and Inflammation

    Linker histone H1.2 and H1.4 affect the neutrophil lineage determination

    Gabriel Sollberger et al.
    Linker histones affect the lineage determination of granulocyte precursor cells via regulation of the transcription factor GATA-2.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

    Anneke Dixie Kakebeen et al.
    Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.

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