Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.
Timothy J Abreo, Emma C Thompson ... Edward C Cooper
A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
The vaginal immunoproteome in pregnancy is more predictive of spontaneous preterm birth (sPTB) than maternal characteristics alone, with sPTB cases showing heightened pro-inflammatory profiles accompanied by reduced levels of antimicrobial proteins/peptides.
A novel neurodevelopmental role for FMRP in collaboration with MAP1B, jointly orchestrating neuronal migration by influencing the microtubular cytoskeleton.
Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
Nguyen Thi Khanh Nhu, Minh-Duy Phan ... Mark A Schembri
E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.