55 results found
    1. Genetics and Genomics

    3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

    Khanh B Trang, Matthew C Pahl ... Struan FA Grant
    Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.
    1. Genetics and Genomics
    2. Neuroscience

    Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

    Timothy J Abreo, Emma C Thompson ... Edward C Cooper
    A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
    1. Evolutionary Biology

    Fecal Microbiomes: Baboons, bacteria, and biological clocks address an age-old question

    Amanda D Melin
    Studying the fecal microbiota of wild baboons helps provide new insight into the factors that influence biological aging.
    Version of Record
    Insight
    1. Neuroscience

    Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range

    Pál Barzó, Ildikó Szöts ... Gábor Tamás
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Impact of liver specific survival motor neuron (SMN) depletion on peripheral and central nervous system tissue pathology

    Monique Marylin Alves de Almeida, Yves De Repentigny ... Rashmi Kothary
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Cingulate cortex shapes early postnatal development of social vocalizations

    Gurueswar Nagarajan, Denis Matrov ... Yogita Chudasama
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Medicine

    The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study

    Zachary Shaffer, Roberto Romero ... Nardhy Gomez-Lopez
    The vaginal immunoproteome in pregnancy is more predictive of spontaneous preterm birth (sPTB) than maternal characteristics alone, with sPTB cases showing heightened pro-inflammatory profiles accompanied by reduced levels of antimicrobial proteins/peptides.
    1. Neuroscience

    FMRP regulates postnatal neuronal migration via MAP1B

    Salima Messaoudi, Ada Allam ... Isabelle Caille
    A novel neurodevelopmental role for FMRP in collaboration with MAP1B, jointly orchestrating neuronal migration by influencing the microtubular cytoskeleton.
    1. Medicine

    Fungal–bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

    Peigen Chen, Haicheng Chen ... Xing Yang
    Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
    1. Microbiology and Infectious Disease

    High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

    Nguyen Thi Khanh Nhu, Minh-Duy Phan ... Mark A Schembri
    E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.

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