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    1. Neuroscience

    Neurobehavioral evidence of interoceptive sensitivity in early infancy

    Lara Maister et al.
    Pre-verbal infants demonstrate an implicit sensitivity to interoceptive sensations, which fluctuates spontaneously during emotional processing and guides audiovisual preferences in the environment.
    1. Neuroscience

    Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

    Calogero Maria Oddo et al.
    Delivering specific patterns of electrical activity to the median nerve of the arm triggers reliable sensations of texture, suggesting that it may ultimately be possible to restore complex tactile information to users of prosthetic limbs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

    Rodney Elwood Infante, Arun Radhakrishnan
    A post-lysosomal cholesterol transport inhibitor reveals how the endoplasmic reticulum membrane regulates total cellular cholesterol by constantly monitoring a critical pool of cholesterol in the plasma membrane.
    1. Immunology and Inflammation

    Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells

    Dong Hyun Kim et al.
    Cellular immunological and biochemical analyses reveal how decoy IL-1RII is induced by human CD4+ T cells upon TCR-stimulation and regulates the Th17-Treg balance by modulating IL-1β responsiveness in IL-1RI+ cells.
    1. Cell Biology

    Automated cell-type classification in intact tissues by single-cell molecular profiling

    Monica Nagendran et al.
    The ability to rapidly stain for any combination of genes in intact tissue with automated quantification of transcripts in individual cells and spatial re-mapping affords new insights into lung biology, and will greatly accelerate progress in scientific and medical research.
    1. Neuroscience

    Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

    Jui-Yi Hsieh et al.
    Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global genome diversity of the Leishmania donovani complex

    Susanne U Franssen et al.
    Genomic data for the parasites that cause visceral leishmaniasis provides the first global picture of the diversity and evolution of the pathogen and the epidemiology of this fatal tropical disease.
    1. Neuroscience

    Corollary discharge in precerebellar nuclei of sleeping infant rats

    Didhiti Mukherjee et al.
    Infant rats distinguish between self- and other-generated movements, and they do so primarily when moving during active sleep.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

    Takeshi Katsuda et al.
    Human chemically induced liver progenitors (hCLiPs), which are generated from primary human hepatocytes, exhibit the potential to repopulate injured livers of host mice with efficiency > 90%.
    1. Neuroscience

    Cerebellar patients have intact feedback control that can be leveraged to improve reaching

    Amanda M Zimmet et al.
    A control system model of cerebellar patients' movements provides insight into the cerebellum's role in reaching and informs a virtual reality intervention to improve patient reaches.