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    1. Neuroscience

    Corollary discharge in precerebellar nuclei of sleeping infant rats

    Didhiti Mukherjee et al.
    Infant rats distinguish between self- and other-generated movements, and they do so primarily when moving during active sleep.
    1. Genetics and Genomics

    Gene Regulation: Spreading good news

    Jeffrey A Fawcett, Hideki Innan
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

    Rodney Elwood Infante, Arun Radhakrishnan
    A post-lysosomal cholesterol transport inhibitor reveals how the endoplasmic reticulum membrane regulates total cellular cholesterol by constantly monitoring a critical pool of cholesterol in the plasma membrane.
    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Nothobranchius furzeri, an 'instant' fish from an ephemeral habitat

    Martin Reichard, Matej Polačik
    The turquoise killifish from ephemeral pools in African savannah combines extremely short lifespan with a standard vertebrate body plan – ideal attributes for a laboratory animal.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development

    Jia Zhao et al.
    In vivo imaging reveals that gradually increased amount of glucose mediates the heterogeneous functional development of individual β-cells by activating its major downstream calcineurin/NFAT signaling pathway.
    1. Neuroscience

    Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

    Calogero Maria Oddo et al.
    Delivering specific patterns of electrical activity to the median nerve of the arm triggers reliable sensations of texture, suggesting that it may ultimately be possible to restore complex tactile information to users of prosthetic limbs.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles

    Maia Azubel et al.
    Specific attachment of molecularly defined gold nanoparticles enables precise localization, critical for structural studies in vivo, of proteins of unknown structure within the cellular milieu by cryo-electron tomography.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

    Christopher John Schlicksup et al.
    Small molecule antivirals that drive assembly of HBV capsid protein can also bind to pre-assembled capsids causing them to change morphology or even break, suggesting a complex transduction of binding effects across the capsid.
    1. Neuroscience

    Semi-intact ex vivo approach to investigate spinal somatosensory circuits

    Junichi Hachisuka et al.
    A new spinal somatosensory preparation is described which enables fine control of sensory input and the ability to manipulate spinal interneurons while recording from spinal projection neurons.