4,939 results found
    1. Epidemiology and Global Health

    Enteropathogen antibody dynamics and force of infection among children in low-resource settings

    Benjamin F Arnold et al.
    Among children in low-resource settings, diverse enteropathogens share common, population-level antibody dynamics, which creates a new opportunity to estimate transmission through serologic surveillance.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

    Anastasia A Minervina et al.
    Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

    Kunal Sharma et al.
    Live-cell imaging captures the heterogenity of bacterial growth within intracellular bacterial communities and demonstrates that the constituent bacteria are protected from clearance by antibiotics delivered with a physiologically relevant pharmacodynamic profile.
    1. Microbiology and Infectious Disease

    Single-cell transcriptional dynamics of flavivirus infection

    Fabio Zanini et al.
    A novel virus-inclusive single cell RNA-Seq approach enables identification of novel pro- and antiviral host factors in human cells in response to dengue and Zika virus infection.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimating SARS-CoV-2 seroprevalence and epidemiological parameters with uncertainty from serological surveys

    Daniel B Larremore et al.
    Integrating over multiple forms of statistical uncertainty associated with serological surveys can improve serosurvey design while also enabling that uncertainty to be appropriately propagated through epidemiological models.
    1. Epidemiology and Global Health

    Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics

    Kevin C Ma et al.
    Racial and ethnic disparities in SARS-CoV-2 infection rates can impact overall epidemic dynamics and herd immunity, underscoring the need to develop socially informed transmission models that account for population variability.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

    Lu Yu et al.
    Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The mobility of packaged phage genome controls ejection dynamics

    Alex Evilevitch
    Temperature and ionic conditions control the mechanical properties of virally encapsidated DNA and act as a switch between synchronized and desynchronized genome ejection dynamics in a phage population.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

    Pengxing Cao et al.
    A mathematical model of blood-stage infection with Plasmodium falciparum malaria capturing the sexual stage of the parasite life-cycle is validated against human data, providing new insight into human-to-mosquito transmission.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The distribution of antibiotic use and its association with antibiotic resistance

    Scott W Olesen et al.
    Population-level antibiotic resistance correlates with the breadth of antibiotic use, that is, the proportion of people taking an antibiotic, better than with intensity of use the amount of use among users.

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