126 results found
    1. Neuroscience

    Diverse inhibitory projections from the cerebellar interposed nucleus

    Elena N Judd et al.
    Inhibitory cerebellar feedback to the inferior olive is central to computational models of learning, but novel targets of these neurons identified here expand their potential roles.
    1. Neuroscience

    Decoding the brain state-dependent relationship between pupil dynamics and resting state fMRI signal fluctuation

    Filip Sobczak et al.
    The variability of the pupil–fMRI relationship was characterized through a combination of clustering and prediction methods, which revealed brain state-specific subcortical and neuromodulatory activation patterns reflected in pupil dynamics.
    1. Developmental Biology
    2. Neuroscience

    Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

    Meike E van der Heijden et al.
    Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.
    1. Neuroscience

    Single-cell and single-nucleus RNA-seq uncovers shared and distinct axes of variation in dorsal LGN neurons in mice, non-human primates, and humans

    Trygve E Bakken et al.
    Transcriptomic differences between relay neurons in the mature mammalian dLGN are subtle relative to striking differences in morphology and cortical projection targets.
    1. Neuroscience

    Transcriptomic encoding of sensorimotor transformation in the midbrain

    Zhiyong Xie et al.
    Single-cell RNA-sequencing and neural circuitry analyses reveal that sensorimotor transformation of different behaviors which are performed by separate circuit modules in the superior colliculus are molecularly defined by distinct transcriptomic codes of specific neuron subtypes.
    1. Neuroscience

    Sensory coding and the causal impact of mouse cortex in a visual decision

    Peter Zatka-Haas et al.
    Local sensory signals in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not.
    1. Neuroscience

    Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons

    Gabriel E Romero, Laurence O Trussell
    In a fast brainstem relay controlling hearing sensitivity, descending synaptic control from midbrain provides the dominant source of excitation, due to a distinct form of synaptic plasticity.
    1. Neuroscience

    Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity

    Tom P Franken et al.
    The location of impact sounds, common stimuli whose detection is crucial for survival, is encoded by a precise interaction between excitation and inhibition rather than coincidence detection of excitatory events.
    1. Neuroscience

    The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

    Emily G Berghoff et al.
    Circuit transcription factors may define the differentiation and assembly of distinct neurons into functional circuitry.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding et al.
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.

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