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887 results found
    1. Neuroscience

    Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network

    Yaara Lefler et al.
    Non-synaptic electrical events recorded simultaneously from pairs of neurons in the inferior olive nucleus enables accurate estimation of the size and of the clustered organization of the electrically coupled network.
    1. Neuroscience

    Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters

    Josef Turecek, Wade G Regehr
    Inhibition from the cerebellar nuclei to the inferior olive is exclusively asynchronous and GABAergic, whereas the vestibular nuclei provide rapid synchronous inhibition mediated by mixed GABA and glycinergic synapses.
    1. Neuroscience

    Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1

    Terri M Driessen et al.
    Unbiased transcriptomics reveals novel insights into the mechanisms that may contribute to regional neurodegeneration in SCA1, and other SCAs in general.
    1. Neuroscience

    Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning

    Yan Yang, Stephen G Lisberger
    During learning, one climbing fiber input instructs plasticity that is expressed in the simple-spike responses of cerebellar Purkinje cells, and causes neural learning that may inhibit future climbing fiber instructions.
    1. Neuroscience

    Corollary discharge in precerebellar nuclei of sleeping infant rats

    Didhiti Mukherjee et al.
    Infant rats distinguish between self- and other-generated movements, and they do so primarily when moving during active sleep.
    1. Neuroscience

    Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

    Hirofumi Fujita et al.
    Medial cerebellar nucleus comprises five major types of excitatory projection neurons differentially connected with specific subsets of inferior olive neurons, Purkinje cells, and somatomotor, oromotor, positional-autonomic, orienting and arousal circuits.
    1. Neuroscience

    Cerebellar learning using perturbations

    Guy Bouvier et al.
    A proposal for a complete cellular/network implementation of trial-and-error motor learning in the olivo-cerebellar system.
    1. Neuroscience

    Principles of operation of a cerebellar learning circuit

    David J Herzfeld et al.
    Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene

    Augusto Berrocal et al.
    Live quantitative monitoring of transcriptional bursting reveals that enhancers responding to different regulators use the same kinetic strategy to produce a complex composite pattern of developmental expression.
    1. Developmental Biology

    Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer

    Barbara Tavares et al.
    Foxj1a makes cilia ultrastructurally motile, while Notch signalling stops cilia movement in Kupffer's vesicle.

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