556 results found
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

    Nima Etemadi et al.
    Intrinsic defects in keratinocytes can cause skin inflammation through excessive cell death and production of inflammatory molecules.
    1. Cell Biology
    2. Developmental Biology

    TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

    James A Rickard et al.
    Skin inflammation in Sharpin-deficient mice is primarily due to TNFR1-dependent apoptosis, but necroptosis appears to play a bigger role in inflammation of internal organs.
    1. Cell Biology

    Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

    Sharan Janjuha et al.
    During aging, the pancreatic endocrine islets undergo chronic inflammation, which is associated with a reduced capacity for self-renewal of the insulin-producing beta-cells in zebrafish.
    1. Immunology and Inflammation

    Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

    Yasunobu Arima et al.
    A link between chronic stress and organ dysfunction is explained by the gateway reflex, in which brain micro-inflammation at specific vessels establishes a new neural pathway to induce fatal organ failure particularly in gastrointestine and heart.
    1. Cell Biology

    Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

    Jonathan Mowers et al.
    Reduced energy expenditure in obesity may result from reduced sensitivity to sympathetic activation due to inflammation-generated signals in adipose tissue.
    1. Cell Biology
    2. Immunology and Inflammation

    Apoptosis: Keeping inflammation at bay

    David Wallach, Andrew Kovalenko
    Insight
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    1. Cell Biology
    2. Immunology and Inflammation

    Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

    Snehlata Kumari et al.
    The adaptor proteins FADD and TRADD play an important role in the Sharpin-dependent anti-apoptosis signaling pathway in keratinocytes and regulate skin homeostasis.
    1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Immunology and Inflammation

    The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

    Agnieszka M Kabat et al.
    Impaired autophagy influences intestinal inflammation and hypersensitivity responses by orchestrating mucosal T cell populations, suggesting new translational perspectives for the treatment of these conditions.

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