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    1. Cell Biology
    2. Immunology and Inflammation

    Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

    Snehlata Kumari et al.
    The adaptor proteins FADD and TRADD play an important role in the Sharpin-dependent anti-apoptosis signaling pathway in keratinocytes and regulate skin homeostasis.
    1. Neuroscience

    One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

    Austin D Hocker et al.
    A single neonatal inflammatory event induces long-term impairments in two forms of adult respiratory motor plasticity, an important aspect of the control of breathing for compensation after injury or disease.
    1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Cell Biology
    2. Human Biology and Medicine

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Immunology and Inflammation

    The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

    Agnieszka M Kabat et al.
    Impaired autophagy influences intestinal inflammation and hypersensitivity responses by orchestrating mucosal T cell populations, suggesting new translational perspectives for the treatment of these conditions.
    1. Neuroscience

    Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

    Seungkyu Lee et al.
    A cationic molecule derived from an uncharged Cav2.2 calcium channel inhibitor powerfully inhibits both sodium and calcium channels with extracellular application and inhibits both pain and neurogenic inflammation.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

    Thomas Scambler et al.
    Dysfunction and overexpression of ENaC-mediated sodium influx exacerbates activation of NLRP3-inflammasome mediated inflammation in cells with CF-associated mutations and is modulated by inhibition of these amiloride-sensitive sodium (Na+) channels.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

    Tanya S Freedman et al.
    Degradation of kinase LynA protects macrophages from activation unless cells sense a receptor-binding pathogen or inflammation