761 results found
    1. Neuroscience

    Different neuronal populations mediate inflammatory pain analgesia by exogenous and endogenous opioids

    Xin-Yan Zhang et al.
    Exogenous opioid analgesia is mediated by MORs expressed in glutamatergic neurons, whereas endogenous opioid analgesia is mediated by MORs expressed in GABAergic neurons.
    1. Neuroscience

    Upregulation of TRPM3 in nociceptors innervating inflamed tissue

    Marie Mulier et al.
    The expression and function of the cation channel TRPM3 is strongly increased in sensory neurons innervating inflamed tissue, likely contributing to inflammatory hyperalgesia and persistent pain.
    1. Neuroscience

    Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin

    Mouloud Bouhadfane et al.
    The pain mediator bradykinin was found to sensitize spinal motoneurons by a direct postsynaptic action, questioning the role of motoneurons in the assessment of hyperalgesia since the withdrawal motor reflex is commonly used as a surrogate pain model.
    1. Neuroscience

    Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators

    Kristen M Smith-Edwards et al.
    Inflammatory pain, previously thought to result from increased activity in "pain" neurons, may in fact be due to wholesale changes in afferent output that includes increased and decreased activity that the brain interprets as pain.
    1. Immunology and Inflammation

    Lung Disease: The soot of all evil

    Derek W Russell, J Edwin Blalock
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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: Hold your breath!

    Katharina Lust, Joachim Wittbrodt
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    1. Immunology and Inflammation

    Autoimmunity: Treating type-1 diabetes with an epigenetic drug

    Yohko Kitagawa, Naganari Ohkura
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    1. Genetics and Genomics

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Parkinson’s Disease: Linking mitochondria to the immune response

    Rebecca L Wallings et al.
    A gene associated with Parkinson’s disease regulates mitochondrial homeostasis, thus affecting innate immunity.
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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Gene Variation: The double-edged sword of evolution

    Etty Kruzel-Davila, Karl Skorecki
    Two gene variants provide different levels of protection against sleeping sickness, but this comes with an increased risk of developing chronic kidney disease.
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