A computational method based on optimal transport enables state-of-the-art alignment between untargeted metabolomic studies and is evaluated on cord blood and cancer datasets.

Targeted manipulations on organotypic cultures show that the retina switches between at least four different metabolic pathways, each with different yields and kinetics, to dynamically adapt to momentaneous energy needs.

A computational framework allows the unsupervised analysis of samples from single cell data across conditions, inference of multicellular programs associated with disease, and meta-analysis of independent patient cohorts.

Identification of importance of Angiopoietin-4 (Angpt4) as a first growth factor that initiates venous specification in the peripheral retina, and Angpt4-dependent mechanism for fluid clearance in the mouse retina.

Wild chimpanzees contrast to humans since adult male chimpanzees do not exhibit physiological indicators of biological embedding of the stress associated to maternal loss early in life.

eIF3, despite being a general translation initiation factor, functions in mRNA-specific regulation, having a profound impact on the synthesis and activation of the MAPK pathway components and ribosomal proteins.

Tregs form an "immunosuppressive ring" around solid tumors that is broken down during adoptive cell therapy and cyclophosphamide combination immunotherapy.

Proteolytic events targeting histones can be harnessed to develop antibodies for neutrophil extracellular traps, improving researchers’ ability to distinguish these chromatin-based structures in human samples.

Vigorous endurance training results in prolongation of cardiac repolarization and increased repolarization instability, mild ventricular fibrosis associated with decrease of the transient outward potassium current, and enhanced arrhythmia susceptibility in canine model.

Hippocampal sharp-wave ripples are not required for rats to successfully perform spatial tasks that rely on memorization of locations at short timescales.