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    1. Genetics and Genomics

    Integrative genomic analysis of the human immune response to influenza vaccination

    Luis M Franco et al.
    By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A systematic view on influenza induced host shutoff

    Adi Bercovich-Kinori et al.
    During host shut-off caused by the Influenza A virus, cellular genes that play important housekeeping roles for the virus are still efficiently translated.
    1. Microbiology and Infectious Disease

    pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

    Kenji Sugiyama et al.
    The host-derived factors, pp32 and APRIL, interact with influenza viral RNA polymerase to support viral genomic RNA synthesis from complementary RNA.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong et al.
    Some of the mutations that occur during influenza evolution can only be tolerated in conjunction with other mutations that increase the stability of a viral protein.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue et al.
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    1. Microbiology and Infectious Disease

    Influenza virus recruits host protein kinase C to control assembly and activity of its replication machinery

    Arindam Mondal et al.
    Host protein kinase C family members regulate influenza virus genome replication by phosphorylating the viral nucleoprotein and controlling assembly of the viral replication machinery.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion

    Tijana Ivanovic, Stephen C Harrison
    The mechanism of membrane-fusion catalysis in influenza viral infection of target cells is robust against the presence of a large fraction of non-productive viral fusion proteins.
    1. Microbiology and Infectious Disease

    Extreme heterogeneity of influenza virus infection in single cells

    Alistair B Russell et al.
    Single-cell mRNA sequencing shows that the impact of infection with influenza virus varies dramatically from one cell to another.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Earliest infections predict the age distribution of seasonal influenza A cases

    Philip Arevalo et al.
    First influenza infections determine susceptibility to future seasonal influenza infection throughout life, and may impact vaccine effectiveness.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Asynchrony between virus diversity and antibody selection limits influenza virus evolution

    Dylan H Morris et al.
    Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.