71 results found
    1. Cell Biology

    Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

    Giuliana Giamundo, Daniela Intartaglia ... Ivan Conte
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Medicine

    Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

    Hyun Beom Song, Laura Campello ... Anand Swaroop
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

    Elise S Bruguera, Jacob P Mahoney, William I Weis
    Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.
    1. Developmental Biology

    Cdhr1a and pcdh15b link photoreceptor outer segments with inner segment calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Piedade, Jakub K Famulski
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics

    Maf-family bZIP transcription factor NRL interacts with RNA-binding proteins and R-loops in retinal photoreceptors

    Ximena Corso-Díaz, Xulong Liang ... Anand Swaroop
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    A non-conducting role of the Cav1.4 Ca2+ channel drives homeostatic plasticity at the cone photoreceptor synapse

    J Wesley Maddox, Gregory J Ordemann ... Amy Lee
    In congenital stationary night blindness type 2, Cav3 channels may maintain cone synaptic output and visual function provided that the nonconducting role of Cav1.4 in cone synaptogenesis remains intact.
    1. Neuroscience

    Hierarchical cortical plasticity in congenital sight impairment

    Roni O Maimon-Mor, Mahtab Farahbakhsh ... Tessa M Dekker
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Neuroscience

    Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

    Moloy T Goswami, Eric Weh ... Thomas J Wubben
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

    Ashley L Cook, Surojit Sur ... Nicolas Wyhs
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle

    Yiyi Chen, Laimdota Zizmare ... Christoph Trautwein
    Targeted manipulations on organotypic cultures show that the retina switches between at least four different metabolic pathways, each with different yields and kinetics, to dynamically adapt to momentaneous energy needs.
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