2,077 results found
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome

    Laura A Lavery et al.
    Dnmt3a regulates gene expression in inhibitory neurons by writing all mCH and some mCG, and MeCP2 reads some of these mCH sites driving a portion of these gene expression changes.
    1. Neuroscience

    A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons

    Kristina D Micheva et al.
    Parvalbumin-positive inhibitory neurons in the cortex have insulating myelin sheathes, despite forming only short-range connections.
    1. Neuroscience

    A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

    Yishan Sun et al.
    A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.
    1. Neuroscience

    CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons

    Paulina Carriba, Alun M Davies
    CD40-activated CD40L-mediated reverse signalling has strikingly opposite effects on the growth of excitatory and inhibitory neuron dendrites in the developing brain of mice.
    1. Neuroscience

    Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis

    Nicolas X Tritsch et al.
    The molecular mechanisms by which midbrain dopamine neurons acquire the inhibitory neurotransmitter GABA for synaptic release are revealed.
    1. Neuroscience

    Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

    Eitan S Kaplan et al.
    Parvalbumin-containing inhibitory neurons are crucial for expression of plasticity in adult visual cortex that supports visual recognition memory, but not for expression of ocular dominance plasticity that results from monocular deprivation.
    1. Neuroscience

    Behavioral-state modulation of inhibition is context-dependent and cell type specific in mouse visual cortex

    Janelle MP Pakan et al.
    The three main types of inhibitory neurons in mouse primary visual cortex respond differently to locomotion in darkness and during visual stimulation, revealing context-dependent responses to changes in behavioral state.
    1. Neuroscience

    Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels

    Kara E Zang et al.
    Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
    1. Neuroscience

    Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn

    Kwan Yeop Lee et al.
    The flow of somatosensory information through the spinal dorsal horn is regulated by synaptic inhibition, which acts upon excitatory and inhibitory interneurons, but the former are especially prone to disinhibition.
    1. Neuroscience

    Alzheimer’s Disease: Identifying faulty brain circuits

    Jesse E Hanson
    A protein called NPTX2 may be a useful marker of neural circuit defects in patients with Alzheimer's disease.
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