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    1. Cell Biology

    Cyclin-dependent kinase control of motile ciliogenesis

    Eszter K Vladar et al.
    Cyclin-dependentkinase 2 (Cdk2), the master regulator of S phase events during the cell cycle, controls the earliest step in the motile ciliogenesis pathway in quiescent multiciliatedairway epithelial cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome

    Priyanka D Abeyrathne et al.
    An ensemble of cryo-EM structures reveals how eukaryotic elongation factor 2 positions the first codon of a viral mRNA for translation.
    1. Structural Biology and Molecular Biophysics

    Mechanisms of ribosome stalling by SecM at multiple elongation steps

    Jun Zhang et al.
    Nascent regulatory peptides tune the translation rate through a continuous, dynamic reshaping of the functional center of the ribosome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conserved MCM single-stranded DNA binding element is essential for replication initiation

    Clifford A Froelich et al.
    The crystal structure of the MCM helicase bound to single-stranded DNA reveals a binding motif that is critical for cell viability, helicase activation and DNA replication.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation

    Yashar Sadian et al.
    Imaging with electron microscopy and cryo-electron tomography reveals that competition between Cdc42 and Gic1 for the same subunit within septins controls the formation and breakdown of septin filaments.
    1. Computational and Systems Biology
    2. Developmental Biology

    Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering

    Maria Abou Chakra et al.
    A mathematical model predicts that cell cycle duration acts as a transcriptional filter and directly affects cell diversity in early eukaryotic development.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of nucleotide selection by telomerase

    Matthew A Schaich et al.
    The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.
    1. Neuroscience

    Functionally asymmetric motor neurons contribute to coordinating locomotion of Caenorhabditis elegans

    Oleg Tolstenkov et al.
    The 'missing' class of Caenorhabditis elegans excitatory motor neurons, AS, contribute to propagation and coordination of body waves, integrating information from, and feeding back to premotor interneurons byelectrical signaling.
    1. Cell Biology
    2. Developmental Biology

    Radially patterned cell behaviours during tube budding from an epithelium

    Yara E Sanchez-Corrales et al.
    Quantitative analysis in quasi-3D reveals apically driven cell behaviours that are closely coordinated across the tissue to allow ordered tube invagination through a focal point.
    1. Neuroscience

    Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

    Nicole Scholz et al.
    Metabotropic mechanosensing occurs through an adhesion-type G protein-coupled receptor.