Neutrophil-dependent innate immune responses to the human pathogen, methicillin-resistant Staphylococcus aureus, are modulated by an interplay between interleukin-21 and type 1 interferons.

An immune system pattern recognition receptor potentiates anti-tumor innate immune responses, offering new insight into anti-tumor activity of the innate immune system.

Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.

Contrary to the current perception, insect eggs are very capable of defending themselves against pathogens.

Ribosome production is unexpectedly integrated into innate cell-intrinsic responses that regulate double strand DNA-sensing and inflammatory cytokine induction in infected and uninfected cells.

The integration of signals via the pleiotropic NF-kappaB (NF-κB) system enables microenvironmental cues to tune cellular responses to pathogenic substances.

Long studied in the context of the central nervous system, LRRK2 also functions in peripheral immunity by maintaining mitochondrial homeostasis in macrophages to regulate the type I interferon response.

Pancreatic α and β cells have different cell autonomous signatures; this explains why α but not β cells can clear infections by potentially diabetogenic viruses.

A group of innate-like lymphocytes surveys the lymph node subcapsular sinus for bacterial and fungal invaders using a novel combination of chemoattractant and adhesion molecules.

Derepression of transcripts from hypomethylated pericentromeric repeats triggers an innate immune response in an animal model of Immunodeficency, Centromere and Facial anomalies (ICF) syndrome.