878 results found
    1. Microbiology and Infectious Disease

    HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport

    Hataf Khan, Rebecca P Sumner ... Greg J Towers
    HIV-1 Vpr antagonises innate immune sensing of viral and non-viral stimuli by preventing activated IRF3 and NF-κB nuclear transport.
    1. Immunology and Inflammation

    Ribosome biogenesis restricts innate immune responses to virus infection and DNA

    Christopher Bianco, Ian Mohr
    Ribosome production is unexpectedly integrated into innate cell-intrinsic responses that regulate double strand DNA-sensing and inflammatory cytokine induction in infected and uninfected cells.
    1. Neuroscience

    Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

    Chang-Hui Tsao, Chien-Chun Chen ... Suewei Lin
    Mushroom bodies are a hunger and satiety integrative center that controls food-seeking behavior in Drosophila..
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60

    Chun Kew, Wenming Huang ... Adam Antebi
    The splicing factor RNP-6/PUF60 suppresses immunity by modulating host splicing and transcriptional responses to infection.
    1. Microbiology and Infectious Disease

    Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism

    See-Yeun Ting, Kaitlyn D LaCourse ... Joseph D Mougous
    Pseudomonas aeruginosa defends against interbacterial antagonism through the coordinated expression of previously uncharacterized pathways that grant threat-specific protection.
    1. Computational and Systems Biology
    2. Neuroscience

    High-throughput automated methods for classical and operant conditioning of Drosophila larvae

    Elise C Croteau-Chonka, Michael S Clayton ... Kristina T Klein
    A novel high-throughput FPGA-based multi-animal tracking and training system was used to demonstrate trace and operant conditioning in Drosophila larvae.
    1. Immunology and Inflammation

    Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

    Naren Srinivasan, Oliver Gordon ... Caetano Reis e Sousa
    Extracellular actin is an evolutionarily-conserved signal of tissue injury that is recognised in the fruit fly via similar machinery as reported in vertebrates.
    1. Immunology and Inflammation

    Perinatal development of innate immune topology

    Philipp Henneke, Katrin Kierdorf ... Mathias Hornef
    At the transition from intrauterine to postnatal life, drastic environmental alterations are mirrored by changes in cellular immunity, which are in part immune cell intrinsic and have lasting health impact.
    1. Developmental Biology
    2. Neuroscience

    UPRER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

    Pengfei Liu, Xinyi Liu, Bin Qi
    The cellular stress response pathway helps animals evaluate food quality and regulate feeding behavior to adapt in nutrient-deficient environments.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

    Kevin G Hicks, Scott P Delbecq ... Samuel I Miller
    Receptor recognition of antimicrobial peptides is important for Salmonellae to survive inside macrophages and cause disease.

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