1,708 results found
    1. Neuroscience

    Subcortico-amygdala pathway processes innate and learned threats

    Valentina Khalil, Islam Faress ... Sadegh Nabavi
    The subcortical amygdala pathway, which has been traditionally associated with learning threats, is also required for processing an innate threat.
    1. Neuroscience

    Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

    Weisheng Wang, Peter J Schuette ... Avishek Adhikari
    Activity in the hypothalamic dorsal premammillary nucleus predicts future escape from threat, represents escape velocity, and controls escape velocity via a projection to the brainstem.
    1. Microbiology and Infectious Disease

    Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism

    See-Yeun Ting, Kaitlyn D LaCourse ... Joseph D Mougous
    Pseudomonas aeruginosa defends against interbacterial antagonism through the coordinated expression of previously uncharacterized pathways that grant threat-specific protection.
    1. Evolutionary Biology
    2. Medicine

    APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population

    Angela R Garcia, Caleb Finch ... Benjamin C Trumble
    The relationship between APOE genotype and disease risks may be environmentally moderated, with APOE4 being less harmful and unlikely to increase cardiometabolic risk in a physically active, energy-limited population.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structural basis for the prion-like MAVS filaments in antiviral innate immunity

    Hui Xu, Xiaojing He ... Qiu-Xing Jiang
    Mitochondrial anti-viral signaling proteins form three-stranded helical filaments in launching innate immune responses against RNA viruses.
    1. Immunology and Inflammation
    2. Medicine

    Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection

    Noah J Silverstein, Yetao Wang ... Jeremy Luban
    Homeostatic innate lymphoid cell abundance, adjusted for age and sex, correlates inversely with COVID-19 severity in adults and children.
    1. Neuroscience

    Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body

    Michael-John Dolan, Shahar Frechter ... Gregory SXE Jefferis
    The generation and systematic characterisation of driver lines labelling a large number of neurons in the Drosophila innate olfactory processing centre bridges electron microscopy neuronal reconstructions, circuits and behaviour.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

    Brian J Ferguson, Daniel S Mansur ... Geoffrey L Smith
    Experiments in mice have shown than an enzyme that repairs broken DNA inside the nucleus also has a central role in the innate immune system because it is able to detect foreign DNA outside the nucleus.
    1. Neuroscience

    Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses

    Jee Yoon Bang, Julia Kathryn Sunstrum ... Junchul Kim
    The hippocampus controls context-dependent defensive behaviors through the anterior hypothalamus, a major component of the medial hypothalamic defense system, by retrieving contextual information essential for avoiding predatory threats and escaping to a safe shelter.
    1. Neuroscience

    The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats

    Miguel Antonio Xavier de Lima, Marcus Vinicius C Baldo ... Newton Sabino Canteras
    The anterior cingulate cortex provides predictive relationships between the context and the predator threat and influences the acquisition and expression of fear memory to predatory threat.

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