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    1. Immunology and Inflammation

    Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis

    Nicholas A Spidale, Nidhi Malhotra ... Joonsoo Kang
    Neonatal-origin dermal Tγδ17 cells are required to maintain normal keratinocytes and prevent spontaneous atopic dermatitis.
    1. Microbiology and Infectious Disease

    Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

    Sem H Jacobs, Eva Dóró ... Maria Forlenza
    Transparent zebrafish, reveal the occurrence of foamy macrophages during an extracellular trypanosome infection and their association with an exacerbated inflammatory response.
    1. Immunology and Inflammation

    C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation

    Chang Hoon Lee, Hongwei H Zhang ... Joshua M Farber
    The bZIP transcription factor C/EBPδ enhances expression both of selectin ligands and the chemokine receptor CCR6 on human mucosal-associated invariant T cells, supporting their efficient extravasation into inflamed tissue.
    1. Immunology and Inflammation

    Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes

    Peng Yang, Yaohui Chen ... Fan Wang
    A novel innate immune cell subset in shrimp shows similarities with human macrophage.
    1. Microbiology and Infectious Disease

    HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread

    Tongcui Ma, Xiaoyu Luo ... Nadia R Roan
    CD4+ T cells from the female reproductive tract are unusually susceptible to HIV infection and are altered by HIV in ways that promote survival and systemic spread of the virus.
    1. Immunology and Inflammation

    Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

    Rimma Laufer Britva, Aviad Keren ... Amos Gilhar
    Innate lymphoid cells type 1 suffice to induce hallmarks of alopecia areata phenotype in organ-cultured human scalp hair follicles ex vivo and in human scalp skin xenotransplants in vivo, suggesting that these cells play a role in early AA pathogenesis.
    1. Developmental Biology
    2. Immunology and Inflammation

    Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain

    Hyun-Woo Jeong, Rodrigo Diéguez-Hurtado ... Ralf H Adams
    Reactive endothelial venules are a new vessel subtype characterized by consistent expression of cell adhesion molecules, preferential leukocyte transmigration, association with perivascular macrophages, and the initiation of CNS immune responses.
    1. Immunology and Inflammation

    Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

    Michael C Kiritsy, Katelyn McCann ... Andrew J Olive
    Complex I of the mitochondrial respiratory chain is necessary for interferon gamma-mediated responses in antigen-presenting cells and is required for CD4+ T cell activation.
    1. Immunology and Inflammation

    Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis

    Jian Liu, YuYing Jiang ... ZhiQiang Yin
    Gasdermin D-mediated neutrophil pyroptosis plays an important role in driving inflammation in psoriasis, which unravels new pathogenesis of psoriasis and provides new insights into psoriasis treatment by targeting neutrophil pyroptosis.
    1. Immunology and Inflammation
    2. Medicine

    Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection

    Noah J Silverstein, Yetao Wang ... Jeremy Luban
    Homeostatic innate lymphoid cell abundance, adjusted for age and sex, correlates inversely with COVID-19 severity in adults and children.