1,685 results found
    1. Cell Biology
    2. Developmental Biology

    Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure

    Ian A Swinburne et al.
    The pressure of fluid in the inner ear is controlled by opening of cellular valves in the endolymphatic sac to allow for regulated transepithelial fluid flow.
    1. Developmental Biology

    Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

    Zoe F Mann et al.
    A dynamic confrontation between Notch signalling and the transcription factor Lmx1a at the borders of the developing inner ear sensory patches regulates their segregation and the positioning of their boundaries.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

    Louise Menendez et al.
    Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
    1. Computational and Systems Biology
    2. Developmental Biology

    Size control of the inner ear via hydraulic feedback

    Kishore R Mosaliganti et al.
    Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.
    1. Cell Biology
    2. Developmental Biology

    Distribution of neurosensory progenitor pools during inner ear morphogenesis unveiled by cell lineage reconstruction

    Sylvia Dyballa et al.
    The first dynamic map of early neuronal and sensory progenitors in the whole otic vesicle reveals how progenitor domains remodel upon morphogenesis.
    1. Developmental Biology
    2. Neuroscience

    Molecular architecture underlying fluid absorption by the developing inner ear

    Keiji Honda et al.
    Genome-wide RNA-seq analysis of single cells of the developing mouse endolymphatic sac reveals its molecular-cellular architecture and a model for salt and fluid absorption required for acquisition of normal inner ear structure and function.
    1. Evolutionary Biology

    Evolution: Mapping the ancestry of primates

    Ignacio Martínez, Mercedes Conde-Valverde
    Structures in the inner ear can help determine the evolutionary relationship between extinct and living primates.
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    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Developmental Biology
    2. Neuroscience

    Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

    Chao Li et al.
    RNA-Seq analysis and in vivo validation via genetic approach uncover that Scrt2 and Celf4 are expressed in inner ear auditory neurons throughout development.
    1. Cell Biology
    2. Neuroscience

    Hearing: It takes two

    Teresa Nicolson
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