2,098 results found
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto et al.
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Neuroscience

    Dynamic dichotomy of accumbal population activity underlies cocaine sensitization

    Ruud van Zessen et al.
    Cocaine elicits opposing activity changes in D1R vs D2R spiny projection neurons of the nucleus accumbens with much variability, subsequent recruitment of a subset of D1R neurons drives behavioral sensitization.
    1. Neuroscience

    Early life experience sets hard limits on motor learning as evidenced from artificial arm use

    Roni O Maimon-Mor et al.
    Biological- or artificial-arm experience during early development has a significant effect on artificial-arm motor control in adulthood, providing evidence for limited sensorimotor plasticity beyond childhood.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Circular RNA repertoires are associated with evolutionarily young transposable elements

    Franziska Gruhl et al.
    Evolutionary analyses suggest that most mammalian circRNAs did not emerge from common ancestral circRNA precursors, arguing against widespread functional conservation.
    1. Neuroscience

    Memory recall involves a transient break in excitatory-inhibitory balance

    Renée S Koolschijn et al.
    Hippocampal activity during memory recall predicts a transient increase in the ratio between neocortical glutamate and GABA, thereby allowing otherwise dormant memories to be released.
    1. Neuroscience

    The generation of cortical novelty responses through inhibitory plasticity

    Auguste Schulz et al.
    Inhibitory synaptic plasticity provides a flexible and biologically plausible circuit mechanism to detect the novelty of bottom-up stimuli and to generate stimulus-specific adaptation.
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon et al.
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Ecology

    A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

    Meret Huber et al.
    An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.
    1. Ecology
    2. Evolutionary Biology

    Social-like responses are inducible in asocial Mexican cavefish despite the exhibition of strong repetitive behavior

    Motoko Iwashita, Masato Yoshizawa
    A new tracking method revealed the social-like interactions in the Mexican blind cavefish, which was thought to be evolutionarily lost, and also demonstrated its mammal-like antagonistic association between the social-like interaction and repetitive behavior.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An improved fluorescent noncanonical amino acid for measuring conformational distributions using time-resolved transition metal ion FRET

    William N Zagotta et al.
    Time-resolved transition metal ion fluorescence resonance energy transfer using a fluorescent, noncanonical amino acid donor and metal ion acceptor measures distances and distance distributions in proteins, allowing the equilibrium distributions among conformational states to be accurately determined.

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