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    1. Neuroscience

    Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

    Guoqiang Wan et al.
    Overexpression of the growth factor neurotrophin-3 helps to repair noise-induced damage in the mouse inner ear by promoting the regeneration of damaged synapses.
    1. Developmental Biology
    2. Neuroscience

    Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

    Stephanie A Bucks et al.
    Cell fate-mapping with genetically-modified mouse models and cellular markers demonstrates that sensory hair cells in the vestibular portion of the inner ear are a dynamic population in adult mice that undergo cell death and replacement under normal conditions.
    1. Cell Biology
    2. Neuroscience

    The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

    Qing Fang et al.
    Two myosin 15 isoforms are required separately for the development and long-term maintenance of hearing.
    1. Developmental Biology
    2. Genetics and Genomics

    Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

    Brent A Wilkerson et al.
    The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.
    1. Developmental Biology
    2. Neuroscience

    Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

    Elvira Diamantopoulou et al.
    Results of a zebrafish whole-animal chemical screen for compounds that can rescue ear and myelination defects in an adhesion GPCR (Adgrg6/Gpr126) mutant.
    1. Cell Biology
    2. Neuroscience

    Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells

    A Catalina Vélez-Ortega et al.
    The remarkable lifelong stability of mechanotransducing stereocilia of the inner ear hair cells depends on the activity of the transduction ion channels located at the tips of these mechanosensory projections.
    1. Chromosomes and Gene Expression

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Cell Biology
    2. Developmental Biology

    Flattop regulates basal body docking and positioning in mono- and multiciliated cells

    Moritz Gegg et al.
    In cell types that acquire planar cell polarity, the protein Flattop regulates basal body docking and positioning.
    1. Evolutionary Biology

    The evolution of the vestibular apparatus in apes and humans

    Alessandro Urciuoli et al.
    The morphology of the inner ear distinguishes major anthropoid clades and enables the proposal of various shared-derived features for apes as a whole, lesser apes, and great apes and humans.
    1. Evolutionary Biology

    Evolution: Mapping the ancestry of primates

    Ignacio Martínez, Mercedes Conde-Valverde
    Structures in the inner ear can help determine the evolutionary relationship between extinct and living primates.
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