3,002 results found
    1. Cell Biology

    Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes

    Elizabeth A Beath, Cynthia Bailey ... Francis J McNally
    Limiting cytoplasmic streaming contributes to maintaining spatial separation of the sperm contents from the female meiotic spindle after fertilization.
    1. Microbiology and Infectious Disease

    Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

    Heiner Atze, Yucheng Liang ... Michel Arthur
    Labeling with 13C and 15N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.
    1. Biochemistry and Chemical Biology

    Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors

    Lisa Goebel, Tonia Kirschner ... Daniel Rauh
    The important oncogene KRasG13C can be targeted by covalently binding nucleotide-analogues, resulting in a locked protein that can no longer induce oncogenic signaling.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

    Damien Detraux, Marino Caruso ... Patricia Renard
    Accumulation of succinate during the in vitro modeling of embryonic stem cell state transition critically regulate cell fate.
    1. Evolutionary Biology
    2. Neuroscience

    Divergent sensory investment mirrors potential speciation via niche partitioning across Drosophila

    Ian W Keesey, Veit Grabe ... Bill S Hansson
    Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

    Jelle van den Ameele, Andrea H Brand
    Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

    John Se Kit Yuen Jr, Michael K Saad ... David L Kaplan
    A simple way to create larger volumes of fat tissue for food purposes may be to grow individual fat cells and mechanically combine them together (rather than directly growing the full tissue).
    1. Neuroscience

    Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

    Doreen Badheka, Yevgen Yudin ... Tibor Rohacs
    Electrophysiological experiments, Ca2+ imaging, and behavioral studies in mice identify the TRPM3 ion channel as a novel target of G-protein βγ subunits.
    1. Neuroscience

    EEG-based detection of the locus of auditory attention with convolutional neural networks

    Servaas Vandecappelle, Lucas Deckers ... Tom Francart
    Convolutional neural networks can decode whether a person is listening to a speaker on the left or right solely from 1 to 2s of EEG data.
    1. Neuroscience

    Polyglycerol-opioid conjugate produces analgesia devoid of side effects

    Sara González-Rodríguez, Mohiuddin A Quadir ... Christoph Stein
    A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.

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