Elizabeth A Beath, Cynthia Bailey ... Francis J McNally
Limiting cytoplasmic streaming contributes to maintaining spatial separation of the sperm contents from the female meiotic spindle after fertilization.
Labeling with 13C and 15N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.
The important oncogene KRasG13C can be targeted by covalently binding nucleotide-analogues, resulting in a locked protein that can no longer induce oncogenic signaling.
Phototaxis and courtship behavioral preferences reflect strong correlation with differences in olfactory and visual nervous system investment across five monophyletic Drosophila species, and could help explain their speciation events.
Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.
John Se Kit Yuen Jr, Michael K Saad ... David L Kaplan
A simple way to create larger volumes of fat tissue for food purposes may be to grow individual fat cells and mechanically combine them together (rather than directly growing the full tissue).
Electrophysiological experiments, Ca2+ imaging, and behavioral studies in mice identify the TRPM3 ion channel as a novel target of G-protein βγ subunits.
Sara González-Rodríguez, Mohiuddin A Quadir ... Christoph Stein
A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.