Studying the earliest events in B cell activation reveals that the B cell antigen receptor is opened and activated via the phosphorylation and binding by the spleen tyrosine kinase (Syk).

Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.

Structure-function analyses reveal the mechanistic underpinnings of inside-out transmembrane signaling that controls periplasmic proteolysis, and thereby biofilm formation, in bacteria and may be relevant in the context of other signaling proteins with similar control elements.

Caged, photoactivatible sphingosine localized to mitochondria permits demonstration of the importance of subcellular localization on lipid metabolism and signaling.

Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.

Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.

Pathological vessel leakage in mouse retinopathy models depends on VE-cadherin Y685 phosphorylation status, which in turn is regulated by a signaling cascade originating with VEGFR2 Y949 phosphorylation.

Puzzle-shape cells in the epidermis of many plants form due to a development constraint based on mechanical forces.

Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.

A newfound signaling enzyme that diverged from a protein family ubiquitous in bacteria provides mechanistic insights into how new signaling activity emerges to control distinct cellular function and physiology.