Studying the earliest events in B cell activation reveals that the B cell antigen receptor is opened and activated via the phosphorylation and binding by the spleen tyrosine kinase (Syk).

Structure-function analyses reveal the mechanistic underpinnings of inside-out transmembrane signaling that controls periplasmic proteolysis, and thereby biofilm formation, in bacteria and may be relevant in the context of other signaling proteins with similar control elements.

Transcriptomics is shedding new light on the relationship between photosynthetic algae and salamander eggs.

A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.

The same genes and signaling pathways control the formation of limbs in vertebrates, arthropods and cuttlefish.

Understanding the coordination of the forces generated in embryos by two processes, convergent extension and convergent thickening, is key to understanding how a hollow sphere of cells develops into an elongated embryo.

The structures of the bovine and human BBSome reveal that a conformational change is required to recruit the complex to the ciliary membrane.