In models of chronic migraine, neuronal complexity is diminished in head-pain processing regions but restored through HDAC6 inhibition, which increases tubulin acetylation and cytoskeletal flexibility, and CGRP receptor blockade.
Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.
Genetic analyses reveal that the tropism towards specific Kras driver mutations during urethane carcinogenesis appears to arise from the selection of an oncogenic mutation in normal cells that imparts a narrow window of signaling conducive for tumorigenesis.
The direct interaction of R-type Ca2+ channel Cav2.3 and GABAB receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABAB receptor activation.
Computational modeling, and empirical behavioral and EEG results show that learning relies not only on comparing current events to past experience, but integrates response-based outcome predictions and confidence.
Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
Biological aging processes and age-related diseases demonstrate sexual dimorphism where complex interactions between underlying aging mechanisms and sex chromosomes and hormones are seen in humans and animals.
Actively regulated immune memory differentiation, with a preference for cross-reactive receptors with moderate affinity against pathogens as opposed to high-affinity receptors, confers a long-term benefit to the host.
Differences in the lipid solvation energetics of associated and dissociated states is a primary driving force for membrane protein oligomerization, presenting a molecular mechanism for lipid regulation in biology.