7,733 results found
    1. Ecology

    Stability and asynchrony of local communities but less so diversity increase regional stability of Inner Mongolian grassland

    Yonghui Wang, Shaopeng Wang ... Bernhard Schmid
    The regional stability across distant local communities is related to the stability of and asynchronous dynamics among local communities, which are strongly impacted by population dynamics of a few abundant species and relative weakly by species diversity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

    Mahmoud M Elguindy, Florian Kopp ... Joshua T Mendell
    Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.
    1. Cancer Biology
    2. Computational and Systems Biology

    Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

    Andrew R Lynch, Nicholas L Arp ... Mark E Burkard
    Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

    Huiyun Lyu, Guohua Yuan ... Yan Shi
    Multidimensional study of signaling pathways and epigenomics investigates how TCR (T cell receptor) signaling and chromatin landscape interpaly and impact on Treg stability.
    1. Neuroscience

    Invariant representation of physical stability in the human brain

    RT Pramod, Michael A Cohen ... Nancy Kanwisher
    Scenario-invariant representation of physical stability is found in the frontoparietal regions but not the ventral visual pathway (and ImageNet-trained convolutional neural networks), consistent with the hypothesis that computations underlying physical stability may entail forward simulations of what will happen next.
    1. Genetics and Genomics
    2. Neuroscience

    Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

    Marina Kovalenko, Serkan Erdin ... Vanessa C Wheeler
    Genetic knockout of Hdac2 modifies molecular and cellular phenotypes in Huntington’s disease mice and has a prominent transcriptional regulatory role in adult medium spiny neurons.
    1. Cancer Biology
    2. Genetics and Genomics

    High-grade serous ovarian carcinoma organoids as models of chromosomal instability

    Maria Vias, Lena Morrill Gavarró ... James D Brenton
    Fifteen continuous high-grade serous ovarian carcinoma patient-derived organoids are characterized by transcriptomic, genomic, and drug sensitivity assays to reveal that they comprise communities of clonal populations and represent models of different causes of chromosomal instability and degrees of genome complexity.
    1. Neuroscience

    A stochastic world model on gravity for stability inference

    Taicheng Huang, Jia Liu
    Empirical experiments and computational modeling reveal a stochastic world model on gravity for stability inference that represents gravity’s vertical direction as a Gaussian distribution.
    1. Chromosomes and Gene Expression

    Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

    Rajesh K Yadav, Carolyn M Jablonowski ... Janet F Partridge
    Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.
    1. Developmental Biology
    2. Neuroscience

    Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

    Tamsin J Samuels, Aino I Järvelin ... Ilan Davis
    Single molecule mRNA imaging uncovers post-transcriptional regulation of myc mRNA, via a cell-intrinsic mechanism allowing individualised control of neural stem cell proliferation during Drosophila brain development.

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