Leon Y Chan, Christopher F Mugler ... Karsten Weis
Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
Hongchang Zhao, Stella R Hartono ... Jacqueline Barlow
Genetic analysis of senataxin and RNase H2-deficient mice reveals that genome stability during class switch recombination and antibody generation can be uncoupled, suggesting a role for R loop metabolism dysfunction in lymphomagenesis in patients without immune deficiency.
A theoretical framework for the growth of microtubules quantifies the roles of geometry, mechanics, kinetics and randomness and provides a phase diagram for dynamic instability in these self-assembled polymers.
Jesús Pérez-Ortega, Tzitzitlini Alejandre-García, Rafael Yuste
Spontaneous and visually evoked neuronal ensembles in mouse visual cortex can last for weeks, potentially supporting the long-lasting representation of perceptions and memories.
When a protein involved in DNA repair malfunctions, it can anneal RNA molecules to DNA molecules, creating hybrids that increase the frequency of mutations in the DNA.
Ana Maria G Dumitru, Scott F Rusin ... Duane A Compton
Quantitative phosphoproteomics defines the substrates for Cyclin A/Cdk1 kinase during early mitosis and follow up studies validate that one identified substrate, MYPT1, influences the stability of k-MT attachments by regulating Plk1.
Chromosomal instability induced in solid tumors can combine with macrophages that are made highly phagocytic to thereby initiate elimination of and immunity against poorly immunogenic tumors in immunocompetent mice.
A Catalina Vélez-Ortega, Mary J Freeman ... Gregory I Frolenkov
The remarkable lifelong stability of mechanotransducing stereocilia of the inner ear hair cells depends on the activity of the transduction ion channels located at the tips of these mechanosensory projections.
