880 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Neuroscience

    DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels

    James P Bohnslav, Nivanthika K Wimalasena ... Christopher D Harvey
    DeepEthogram automatically classifies animal behavior videos into researcher-defined behaviors of interest, saving researcher time and enabling more detailed downstream analysis of behavior.
    1. Neuroscience

    Effects of visual inputs on neural dynamics for coding of location and running speed in medial entorhinal cortex

    Holger Dannenberg, Hallie Lazaro ... Michael E Hasselmo
    Spatial accuracy of grid cell firing correlates with the slope of the local field potential theta frequency vs. running speed relationship and integrates velocity signals over past time.
    1. Cell Biology
    2. Neuroscience

    Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

    Kentarou Baba, Wataru Yoshida ... Naoyuki Inagaki
    Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.
    1. Computational and Systems Biology
    2. Neuroscience

    FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch

    Zachary Daniel Burkett, Nancy F Day ... Stephanie A White
    Basal ganglia gene coexpression patterns shift across the sensorimotor critical period for vocal learning.
    1. Genetics and Genomics

    A confinable home-and-rescue gene drive for population modification

    Nikolay P Kandul, Junru Liu ... Omar S Akbari
    Generation of a home-and-rescue gene drive targeting an essential gene reveals confinable population modification.
    1. Neuroscience

    Temporal cascade of frontal, motor and muscle processes underlying human action-stopping

    Sumitash Jana, Ricci Hannah ... Adam R Aron
    The sequence of neural and physiological processes underlying action-stopping has been delineated.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells

    Scott M Emrich, Ryan E Yoast ... Mohamed Trebak
    Gene knockout in cell lines and mice reveal that store-operated calcium entry is synergistically mediated by Orai1 and Orai3 channel proteins in B cells and is important for signaling to the nucleus and metabolic activity in response to antigenic stimulation.
    1. Neuroscience

    Slowing the body slows down time perception

    Rose De Kock, Weiwei Zhou ... Martin Wiener
    The perception of time is influenced by movement environments, with slower movements associated with shorter perceived time intervals.
    1. Neuroscience

    Neural encoding of actual and imagined touch within human posterior parietal cortex

    Srinivas Chivukula, Carey Y Zhang ... Richard A Andersen
    Single neurons in human posterior parietal cortex encode actual and imagined touch within a shared neural substrate.

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