300 results found
    1. Cancer Biology
    2. Immunology and Inflammation

    Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

    Helene Rundqvist et al.
    Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.
    1. Neuroscience

    C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity

    Tsung-Yuan Hsu et al.
    The olfactory learning of Caenorhabditis elegans shows that the exonuclease and helicase domains of human Werner syndrome protein (WRN) coordinately regulate the biogenesis of small interfering RNAs to promote neuronal plasticity.
    1. Neuroscience

    Thalamic reticular control of local sleep in mouse sensory cortex

    Laura MJ Fernandez et al.
    Local cortical sleep features arise subcortically due to heterogeneous burst discharge in neurons of a sleep rhythm pacemaker previously thought to act uniformly.
    1. Neuroscience

    Transformation of temporal sequences in the zebra finch auditory system

    Yoonseob Lim et al.
    Songbirds discriminate synthetic sounds composed of temporal patterns of clicks, which they transform into distinct ensemble or spatial patterns in successive stages of neural auditory processing.
    1. Neuroscience

    Retroactive modulation of spike timing-dependent plasticity by dopamine

    Zuzanna Brzosko et al.
    Dopamine, a reward signal in the brain, can retroactively convert hippocampal synaptic depression into potentiation, suggesting an elegant biological solution to the distal reward problem.
    1. Immunology and Inflammation

    CD8+ T cell self-tolerance permits responsiveness but limits tissue damage

    Emily N Truckenbrod et al.
    Identification and characterization of the responses of T lymphocytes that are specific for 'self' tissue antigens, revealing the functional limits of immune tolerance.
    1. Neuroscience
    2. Physics of Living Systems

    Walking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters

    Mahmut Demir et al.
    Visualized odor encounters show that Drosophila navigate spatiotemporally complex odor plumes using random walks biased by the timing of brief and unpredictable odor encounters.
    1. Computational and Systems Biology
    2. Medicine

    Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss

    Anwesha Chaudhury et al.
    Unsteady state modeling of blood cell populations reveals that blood loss triggers a cellular clearance delay and a cellular production increase, and modeling provides earlier detection and individualized patient characterization.
    1. Neuroscience

    Stimulus relevance modulates contrast adaptation in visual cortex

    Andreas J Keller et al.
    Cortex dynamically regulates the flow of sensory information by suppressing responses of non-relevant stimuli through mechanisms of adaptation, while boosting sensory responses that are behaviorally important.
    1. Evolutionary Biology

    High potency of sequential therapy with only β-lactam antibiotics

    Aditi Batra et al.
    Sequential therapy with only β-lactam antibiotics achieves surprisingly high potency by exploiting both low rates of spontaneous resistance emergence and low rates of spontaneous cross-resistance among the drugs in sequence.

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