858 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Transcription mediated insulation and interference direct gene cluster expression switches

    Tania Nguyen et al.
    The formation of mutually exclusive coding and non-coding transcription units contributes to transcriptional interference and insulation at gene clusters and manages state-switching in response to environmental change.
    1. Neuroscience

    Anterior insular cortex plays a critical role in interoceptive attention

    Xingchao Wang et al.
    Anterior insular cortex activity predicts how well we attend to our bodily signals, while lesions to this brain region disrupt this ability.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo

    Michael R Stadler et al.
    Fruit fly chromosomes are divided into discrete structural domains by regions of decompacted chromatin, suggesting a novel model for the formation of a known class of genetic elements.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

    Bryan J Matthews, David J Waxman
    Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
    1. Neuroscience

    A molecular mechanism underlying gustatory memory trace for an association in the insular cortex

    Chinnakkaruppan Adaikkan, Kobi Rosenblum
    The role of CaMKII-GluA1 in the cortex in maintaining a given taste memory trace for an aversive association has been elucidated.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

    Tsutomu Aoki et al.
    A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.
    1. Neuroscience

    Neural basis of somatosensory target detection independent of uncertainty, relevance, and reports

    Pia Schröder et al.
    Neural correlates of somatosensory target detection are restricted to secondary somatosensory cortex, whereas activity in insular, cingulate, and motor regions reflects stimulus uncertainty and overt reports.
    1. Developmental Biology

    Evolution: The beat goes on

    Tobias Wang
    Why is the alligator heart so similar to the hearts of birds and mammals?
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    1. Plant Biology

    Flowering time and seed dormancy control use external coincidence to generate life history strategy

    Vicki Springthorpe, Steven Penfield
    Models of plant behaviour show that flowering early in a warming world is an adaptive strategy to insulate progeny seed behaviour from the affects of climate change.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Piezo Ion Channels: Portraits of a pressure sensor

    Alexander T Chesler, Marcin Szczot
    Near atomic-resolution structures have provided insights into the mechanisms by which the Piezo1 ion channel senses and responds to mechanical stimuli.
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