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    1. Genetics and Genomics
    2. Medicine

    KDM5A mutations identified in autism spectrum disorder using forward genetics

    Lauretta El Hayek et al.
    Successful autism spectrum disorder gene discovery using forward genetics identifies KDM5A, which encodes a histone H3 lysine 4 demethylase, as a disease gene.
    1. Neuroscience

    Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds

    Minhui Ouyang et al.
    Diffusion-MRI-based cerebral cortical microstructure encoding regionally differential dendritic arborization and synaptic formation at birth robustly predicts future 2-year-old cognitive and language outcomes with regionally heterogeneous contribution that exhibits functional selectivity.
    1. Medicine

    Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response

    Matthew D Keefe et al.
    Neurological pathology and chronic activation of the induced stress response are caused by expression of a truncated EIF2B5 in vanishing white matter disease.
    1. Genetics and Genomics

    Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity

    Arpan C Ghosh et al.
    A muscle-derived signaling molecule suppresses excessive accumulation of lipids in the Drosophila adipose tissue by activating the Pi3K/Akt/mTOR signaling cascade in the Drosophila hepatocyte-like cells.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cohesin mutations are synthetic lethal with stimulation of WNT signaling

    Chue Vin Chin et al.
    Hypersensitivity of cohesin-deficient cells to Wnt signaling is concomitant with beta catenin stabilization and offers promise that Wnt agonists could be therapeutically effective in cohesin mutant cancers.
    1. Cell Biology
    2. Developmental Biology

    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

    Clemens Heissenberger et al.
    In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.
  1. Event Report: Aging, Geroscience and Longevity Symposium

    Catch up on our online symposium in which eLife authors showcased their research from the upcoming Aging, Geroscience and Longevity Special Issue.
    1. Cell Biology

    Translation in amino-acid-poor environments is limited by tRNAGln charging

    Natalya N Pavlova et al.
    Amino acid limitation triggers preferential uncharging of glutamine-specific tRNAs and depletes polyglutamine tract-containing proteins from mammalian cells, revealing a potential role for polyglutamine tracts as sensors of glutamine sufficiency.
    1. Medicine

    Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

    Shivani N Mann et al.
    17α-Estradiol, a life-span extending compound, signals through estrogen receptor α (ERα) in the liver and hypothalamus to elicit health benefits in a sex-specific manner.
    1. Genetics and Genomics

    Downregulation of the tyrosine degradation pathway extends Drosophila lifespan

    Andrey A Parkhitko et al.
    The tyrosine degradation pathway reprogramming connects mitochondrial dysfunction, aging, and production of tyrosine-derived neuromediators that can be targeted with an FDA-approved drug, Tigecycline.