Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.

daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.

Feeding and fasting associated alterations in proopiomelanocortin neuronal responses to insulin coordinate glucose metabolism.

Two seemingly distinct cellular stress response pathways that contribute to neurodegeneration after axonal insults are now revealed to be under the control of a single master regulator of the neuronal injury response, the kinase DLK.

Sex-optimal diets have different effects on gene expression in female and male flies.

An improved biosensor sheds new light on tension within proteins.