1,379 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

    Michelle C Ward, Nicholas E Banovich ... Yoav Gilad
    Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.
    1. Developmental Biology

    MicroRNA-934 is a novel primate-specific small non-coding RNA with neurogenic function during early development

    Kanella Prodromidou, Ioannis S Vlachos ... Rebecca Matsas
    Primate-specific miR-934 mediates neurogenesis and downstream neuronal differentiation processes, modulating the expression of genes associated with the subplate, a region most prominent in primates, emerging during early cortical development.
    1. Genetics and Genomics

    Genetic and environmental perturbations lead to regulatory decoherence

    Amanda Lea, Meena Subramaniam ... Julien F Ayroles
    Infection and metabolic syndrome lead to a loss of molecular regulation, and changes in molecular correlations are under genetic control as revealed by the presence of correlation quantitative trait loci.
    1. Cell Biology

    KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon

    Gerard Cantero-Recasens, Cristian M Butnaru ... Vivek Malhotra
    KChIP3 localisation by intracellular calcium oscillations controls mucin release from colonic goblet cells.
    1. Chromosomes and Gene Expression

    Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

    Qinyu Hao, Minxue Liu ... Kannanganattu V Prasanth
    A novel family of nucleolus-enriched ncRNAs forms allele-specific territories on the nucleolar organizing region (NOR)-containing acrocentric chromosomes.
    1. Immunology and Inflammation
    2. Neuroscience

    Development and characterization of a chronic implant mouse model for vagus nerve stimulation

    Ibrahim T Mughrabi, Jordan Hickman ... Stavros Zanos
    Long-term, dose-controlled vagus nerve stimulation (VNS) is feasible in mice using a multi-lab validated implantation procedure, allowing therapeutic testing of VNS in many disease models.
    1. Immunology and Inflammation

    Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

    Takahisa Miyao, Maki Miyauchi ... Taishin Akiyama
    The combination of single-cell analysis and cell fate mapping studies evidenced the presence of AIRE-expressing transit-amplifying thymic epithelial cells, which differentiate into mature medullary thymic epithelial cells expressing tissue-specific antigens.
    1. Genetics and Genomics
    2. Neuroscience

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

    Baher A Ibrahim, Yoshitaka Shinagawa ... Daniel A Llano
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cell Biology
    2. Developmental Biology

    The exocyst complex controls multiple events in the pathway of regulated exocytosis

    Sofía Suárez Freire, Sebastián Perez-Pandolfo ... Mariana Melani
    Gradual downregulation of each of the subunits of the evolutionary-conserved exocyst holocomplex shows that the complex is required for biogenesis, maturation, and exocytosis of secretory granules in Drosophila salivary glands.

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