The unique modus operandi of cone snail venom insulins provides new insight into insulin receptor activation and informs on the design of insulin analogs for the treatment of diabetes.

In vivo quantitative analysis of multi-shell diffusion MRI reveals novel insights into microstructure of human insular cortex and its functional circuits associated with the salience network and cognitive control.

The identification of the insulin binding site 2 by high resolution cryo-EM analysis.

Neural oscillations prior to a stimulus modulate the strength of early and late responses in opposite directions via distinct mechanisms.

Lower mitochondrial coenzyme Q was a consistent feature across multiple in vitro and in vivo models of insulin resistance and was sufficient to cause insulin resistance through increased mitochondrial oxidants.

Zebrafish insulin mutants serve as an innovative platform to identify novel mechanisms regulating glucose homeostasis.

A critical role of aCT in the distinct activation mechanism of insulin receptor and insulin-like growth factor 1 receptor.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.

Intracranial recordings indicate that the insula encodes, in a partially intermixed layout, both static and dynamic cues from different body parts that reflect the intensity of pain experienced by others.

Larger evoked responses during initial cortical processing may reflect states of lower excitability.